NANOJECT™ : Successful and Accurate ID injection

Debiotech‘s innovative NanoJect™ device has been designed to overcome the challenges of classical intradermal delivery techniques, while improving accurate site and dose delivery.

Unlike other intradermal delivery systems, NanoJect™ is made of hollow microneedles with a unique side protected delivery hole. By placing the hole on the side of the needle at a precise depth, the skin can be punctured without coring and without removing any tissue. Because the skin remains intact above the side hole, leakage during injection is prevented and healing is improved. Furthermore, by injecting through the side hole, where the needle does not apply direct pressure on the tissue, liquid can diffuse more easily at a better define and controlled depth. This enables pain free injections of up to 0.5ml in only 5 seconds.

The innovation of NanoJect™ consists in the design of the microneedles produced with MEMS (Micro-Electro Mechanical Systems) technology. By controlling exactly the position and orientation of the side hole on each microneedle, it is possible to target a precise intradermal site and control drug or vaccine distribution. At the same time, the tip of the microneedle can be made extremely sharp and without any protrusion to perfectly enter the skin at a 90° angle.

The MEMS technology used to manufacture the microneedles make them very strong and provides them with excellent biocompatibility properties. Thanks to the MEMS process, NanoJect™ microneedles can be manufactured with high precision at low cost.

NanoJect™ is available in multiple possible configurations: one or several silicon microneedles with a length ranging from 350 to 900 microns, having one or multiple hollow bores connected to a syringe. While every microneedle is smaller than a 33G needle, the dimension of the bore is well adapted for delivery of larger particles and long peptides.

With NanoJect™, human in vivo injections of 100 microliters in less than 2 seconds and up to 500 microliters in less than 5 seconds have been performed in a controlled and reproducible way. These were done without specific preliminary training.

NanoJect™ offers several advantages compared to the standard Mantoux technique: improved usability, reproducibility, reliability, accuracy of dose administration with barely no pain, as well as reduction in risk of needle stick injuries for healthcare workers.

NanoJect™ is protected by multiple patent families. This coverage includes the design and manufacturing process of the microneedles, as well as its packaging and insertion device.